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Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying through a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.
Continue to Iris Biotech GmbHSend request to US distributorChemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-(2,2-dimethylpropylsulfo)-L-tyrosine // Synonyms: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(((neopentyloxy)sulfonyl)oxy)phenyl)propanoic acid,O-[(2,2-dimethylpropoxy)sulfonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-Tyrosine, Fmoc-Tyr( SO3nP)-OH
from €330.00
A derivative for the synthesis of sulfotyrosine-containing peptides by Fmoc-SPPS. Tyrosine sulfation is a post translational modification that occurs on integral membrane and secreted proteins and plays a crucial role in mediating biological processes. Thus, this derivative is useful for the study of site-specific tyrosine sulfation and its effect on peptide stability and activity. The sulfate group of FAA8485 is protected with a neopentyl (nP) group, which is stable to TFA. Neopentyl groups can be removed by treatment with aqueous ammonium acetate (1-2 M, 37 °C water bath, 6-12 hrs) or sodiumazide (50 eq, 70 °C, 16 h).
Regulation of chemokine recognition by site-specific tyrosine sulfation of receptor peptides; L. S. Simpson, J. Z. Zhu, T. S. Widlanski, M. J. Stone; Chem. Biol. 2009; 16(2): 153-61. https://doi.org/10.1016/j.chembiol.2008.12.007.
Phosphate modulates receptor sulfotyrosine recognition by the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). J. P. Ludeman, M. Nazari-Robati, B. L. Wilkinson, C. Huang, R. J. Payne, M. J. Stone; Org. Biomol. Chem. 2015; 13, 2162-2169. https://doi.org/10.1039/C4OB02262A.
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