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Fmoc-L-Aad(5-CO2tBu,tBu)-OH
Chemical name: (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)adipic acid-5-tert-butyloxycarbonyl-6-tert-butyl ester // Synonyms: Fmoc-L-HomoGla(OtBu)2-OH, (S)-2-(Fmoc-amino)adipic acid-5-t-butyloxycarbonyl-6-t-butyl ester, (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-(tert-butoxy)-5-(tert-butoxycarbonyl)-6-oxohexanoic acid, Fmoc-Aad(5-CO2tBu,tBu)-OH
- Product code:FAA8745
- CAS No.:912354-06-4
- Storage temperature:2-8°C
- Formula:C30H37NO8
- Molecular weight:539.63 g/mol
from €400.00
description
Nonnatural amino acid analogue of L-gamma-carboxyglutamic acid (Gla), appropriately protected for Fmoc-based solid-phase peptide synthesis (SPPS). This derivative can be used in structure-activity relationship studies to replace Gla.
references
Reference:
Design and Concise Synthesis of Fully Protected Analogues of L-gamma-Carboxyglutamic Acid; S. Jiang, P. Li, C. C. Lai, J. A. Kelley, P. P. Roller; J. Org. Chem. 2006; 71(19): 7307-7314. https://doi.org/10.1021/jo061037q.
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