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H-L-Cys(DMNB)-OH
Chemical name: S-(4,5-dimethoxy-2-nitrobenzyl)-L-cysteine // Synonyms: S-[(4,5-Dimethoxy-2-nitrophenyl)methyl]-L-cysteine
- Product code:HAA9320
- CAS No.:214633-68-8
- Storage temperature:-20°C
- Formula:C12H16N2O6S
- Molecular weight:316.33 g/mol
- Purity :min.99%
from €193.00
description
This building-block permits incorporation of a photocaged cysteine in a protein. The caging group is removed by UV light leaving the cysteine in place.
references
A method for directed evolution and functional cloning of enzymes; H. Pedersen, S. Hölder, D. P. Sutherlin, U. Schwitter, D. S. King, P. G. Schultz; PNAS 1998; 95(18): 10523-10528. https://doi.org/10.1073/pnas.95.18.10523
Light Activation of Protein Splicing with a Photocaged Fast Intein; W. Ren, A. Ji. H.-W. Ai; J. Am. Chem. Soc. 2015; 137(6): 2155-2158. https://doi.org/10.1021/ja508597d
Light-Activation of DNA-Methyltransferases; J. Wolffgramm, B. Buchmuller, S. Palei, A. Muñoz-López, J. Kanne, P. Janning, M. R. Schweiger, D. Summerer; Angew. Chem. Int. Ed. 2021; 60(24): 13507-13512. https://doi.org/10.1002/anie.202103945
Biosynthetic selenoproteins with genetically-encoded photocaged selenocysteines; R. Rakauskaitë, G. Urbanavièiûtë, A. Rukðënaitë, Z. Liutkevièiûtë, R. Juðkënas, V. Masevièius, S. Klimaðauskas; Chem. Commun. 2015; 51: 8245-8248. https://doi.org/10.1039/C4CC07910H
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