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TT-232 tristrifluoroacetate
Chemical name: H-D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr-NH2 (disulfide bridged) // Synonyms: CAP-232, TLN-232, TT232, TT 232
- Product code:LS-1521
- CAS No.:147159-51-1 (net)
- Formula:C45H58N10O9S2 (net)
- Molecular weight:947.15 (net) g/mol
- Purity :min. 98%
from €172.00
description
TT-232 is a structural analogue of somatostatin, a hormone with significant, selective antiproliferative, anti-inflammatory and antisecretory properties. In contrast to the parent hormone and its “traditional” analogues, this compound has strong and specific growth-inhibitory potential without the wide-ranging endocrine side-effects, including inhibition of insulin secretion provoking diabetes. Its mechanism of action is in line with the so-called signal-transduction therapy, where "internal communication" of cells is corrected without interfering with basic cell functions and machinery. Moreover, TT-232 acts on pyruvate kinase translocation and neurogenic inflammation. In vitro and in vivo studies show a selective antitumor activity with induction of strong apoptosis of cancer cells.
references
Evaluation of the antitumor efficacy of the somatostatin structural derivative TT-232 on different tumor models; M. Tejeda, D. Gaál, L. Hullán, B. Hegymegi-Barakonyi, G. Kéri; Anticancer Res. 2006, 26: 3477-83.
A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity; G. Kéri, J. Erchegyi, A. Horváth, I. Mezõ, M. Idei, T. Vántus, A. Balogh, Z. Vadász, G. Bökönyi, J. Seprõdi, I. Teplán, O. Csuka, M. Tejeda, D. Gaál, Z. Szegedi, B. Szende, C. Roze, H. Kalthoff, A. Ullrich; Proceedings of the National Academy of Sciences 1996; 93; 12513-12518. https://doi.org/10.1073/pnas.93.22.12513.
Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse; K. Elekes, Z. Helyes, L. Kereskai, K. Sándor, E. Pintér, G. Pozsgai, V. Tékus, Á. Bánvölgyi, J. Németh, T. Szűts, G. Kéri, J. Szolcsányi; European Journal of Pharmacology 2008; 578; 313-22. https://doi.org/10.1073/pnas.93.22.12513.
Somatostatin stimulates the migration of hepatic oval cells in the injured rat liver; Y. Jung, S.-H. Oh, R.P. Witek, B.E. Petersen; Liver International 2011; 32; 312-320. https://doi.org/10.1111/j.1478-3231.2011.02642.x
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