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Liraglutide
Chemical name: H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(gamma-Glu-palmitoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH // Synonyms: N26-(Hexadecanoyl-gamma-glutamyl)-(34-arginine)GLP-1-(7-37), (Lys(gamma-Glu-palmitoyl)26,Arg34)-GLP-1 (7-37), One letter Code: HAEGTFTSDVSSYLEGQAAK(gamma-Glu-palmitoyl)EFIAWLVRGRG
- Product code:LS-4050
- CAS No.:204656-20-2
- Formula:C172H265N43O51
- Storage temperature:-20°C
- Molecular weight:3751.26 g/mol
- Purity :min. 99.0%. no single impurity
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description
Glucagon-Like-Peptide-1 (GLP-1) agonist used for the treatment of type 2 diabetes. It is an incretin mimetic stimulating the release and synthesis of insulin into the blood by the intestine in response to food. It is only active in the presence of high circulating glucose levels. It also slows the passage of food through the gut and reduces appetite.
references
Innovative chemical synthesis and conformational hints on the lipopeptide liraglutide; I. Guryanov, A. Bondesan, D. Visentini, A. Orlandin, B. Biondi, C. Toniolo, F. Formaggio, A. Ricci, J. Zanon and W. Cabri; J Pept Sci 2016; 22: 471-9. https://doi.org/10.1002/psc.2890
Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide; J. Lau, P. Bloch, L. Schäffer, I. Pettersson, J. Spetzler, J. Kofoed, K. Madsen, L. B. Knudsen, J. McGuire, D. B. Steensgaard, H. M. Strauss, D. X. Gram, S. M. Knudsen, F. S. Nielsen, P. Thygesen, S. Reedtz-Runge and T. Kruse; Journal of medicinal chemistry 2015; 58: 7370-7380. https://doi.org/10.1021/acs.jmedchem.5b00726
The human GLP-1 analogs liraglutide and semaglutide: absence of histopathological effects on the pancreas in nonhuman primates; C. F. Gotfredsen, A. M. Molck, I. Thorup, N. C. Nyborg, Z. Salanti, L. B. Knudsen and M. O. Larsen; Diabetes 2014; 63: 2486-97. https://doi.org/10.2337/db13-1087
Differential chemistry (structure), mechanism of action, and pharmacology of GLP-1 receptor agonists and DPP-4 inhibitors; J. J. Neumiller; J Am Pharm Assoc (2003) 2009; 49 Suppl 1: S16-29. https://doi.org/10.1331/JAPhA.2009.09078
Liraglutide in type 2 diabetes: from pharmacological development to clinical practice; M. C. Rossi and A. Nicolucci; Acta Biomed 2009; 80: 93-101.
Potential of liraglutide in the treatment of patients with type 2 diabetes; C. F. Deacon; Vasc Health Risk Manag 2009; 5: 199-211. https://doi.org/10.2147/vhrm.s4039
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