Products with DACN

Diazacyyclononynes (DACNs) are versatile tools for the so-called 2^nd generation click reaction, a metal-free strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. DACNs are characterized by high reactivity and stability, both thermally and chemically, as well as high selectivity towards ynophiles. As no metal catalyst is required, DACNs can be employed for copper-free bioorthogonal click chemistry. Additionally, the two endocyclic nitrogens in DACN may serve as additional attachment points for further conjugation, rendering the compound functionally versatile.