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Rink Amide/Knorr/Sieber Resins
The Rink amide linker was developed for the synthesis of C-Terminal peptide. The standard Rink amide resin is cleaved using 10% TFA in DCM, as higher concentrations of acid can cleave the Rink linker from the polystyrene resin, producing highly colored impurities. The use of the Knorr resin avoids this unwanted linker cleavage. Sieber resin is less sterically hindered than Rink resin and thus allows for higher loading in sterically demanding applications than Rink resins. Thus, it is ideally for the synthesis of side-chain protected peptide amides. Cleavage occurs in 1% TFA in DCM.
