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Alkyne-myristic acid
Chemical name: 13-Tetradecynoic acid // Synonyms: Tetradec-13-ynoic acid
- Product code:RL-2055
- CAS No.:82909-47-5
- Formula:C14H24O2
- Storage temperature:2-8°C
- Molecular weight:224.34 g/mol
from €400.00
description
Linker for bioconjugation via Click reaction. Protein acylation with this compound leads to rapid, selective and robust fluorescent detection with chemical reporters.
references
Robust fluorescent detection of protein fatty-acylation with chemical reporters; G. Charron, M. M. Zhang, J. S. Yount, J. Wilson, A. S. Raghavan, E. Shamir and H. C. Hang; J Am Chem Soc 2009; 131: 4967-75. https://doi.org/10.1021/ja810122f
Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry; M. C. Yap, M. A. Kostiuk, D. D. Martin, M. A. Perinpanayagam, P. G. Hak, A. Siddam, J. R. Majjigapu, G. Rajaiah, B. O. Keller, J. A. Prescher, P. Wu, C. R. Bertozzi, J. R. Falck and L. G. Berthiaume; J Lipid Res 2010; 51: 1566-80. https://doi.org/10.1194/jlr.D002790
SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine; H. Jiang, S. Khan, Y. Wang, G. Charron, B. He, C. Sebastian, J. Du, R. Kim, E. Ge, R. Mostoslavsky, H. C. Hang, Q. Hao and H. Lin; Nature 2013; 496: 110-3. https://doi.org/10.1038/nature12038
The biology and enzymology of protein N-myristoylation; T. A. Farazi, G. Waksman and J. I. Gordon; J Biol Chem 2001; 276: 39501-4. https://doi.org/10.1074/jbc.R100042200
The growing impact of click chemistry on drug discovery; H. C. Kolb and K. B. Sharpless; Drug Discov Today 2003; 8: 1128-37. https://doi.org/10.1016/S1359-6446(03)02933-7
Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne "click" chemistry; J. F. Lutz and Z. Zarafshani; Adv Drug Deliv Rev 2008; 60: 958-70. https://doi.org/10.1016/j.addr.2008.02.004
Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives; A. Vila, K. A. Tallman, A. T. Jacobs, D. C. Liebler, N. A. Porter and L. J. Marnett; Chemical research in toxicology 2008; 21: 432-44. https://doi.org/10.1021/tx700347w
Chemical Reporters of Protein Acylation; H. C. N. Y. Hang, NY, US), Charron, Guillaume (NEW YORK, NY, US), Wilson, John P. (NEW YORK, NY, US), Raghavan, Anuradha (NEW HAVEN, CT, US), Zhang, Mingzi (NEW YORK, NY, US), Yang, Yu-ying (STAMFORD, CT, US), Rangan, Kavita (NEW YORK, NY, US), Tsou, Lun K. (NEW YORK, NY, US), Yount, Jacob (BROOKLYN, NY, US); 2010.
Chemical reporters for exploring protein acylation; E. Thinon and H. C. Hang; Biochem Soc Trans 2015; 43: 253-61. https://doi.org/10.1042/BST20150004
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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