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Fmoc-Aca-DIM
Chemical name: 6-((9-Fluorenylmethyl)oxycarbonylamino)-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-hexan-1-ol // Synonyms: Fmoc-Ddax-OH, (9H-fluoren-9-yl)methyl N-[6-(4,4-dimethyl-2,6- dioxocyclohexylidene)-6-hydroxyhexyl]carbamate
- Product code:RL-3260
- CAS No.:2379561-08-5
- Formula:C29H33NO5
- Storage temperature:-20°C
- Molecular weight:475.58 g/mol
- Purity :min. 98%
from €120.00
description
Used as a next-generation traceless "helping hand" solubilizing tag in SPPS. Several Lysine residues are attached to this linker using Fmoc-SPPS. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution. This linker is more stable than its predecessor Fmoc-Ddae-OH.
references
Chemical synthesis of Shiga toxin subunit B using a next-generation traceless "helping hand" solubilizing tag; J. M. Fulcher, M. E. Petersen, R. J. Giesler, Z. S. Cruz, D. M. Eckert, J. N. Francis, E. M. Kawamoto, M. T. Jacobsen and M. S. Kay; Org Biomol Chem 2019; 17: 10237-10244. https://doi.org/10.1039/c9ob02012h
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Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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