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N3-PEG(3)-SQA
Chemical name: 3-((2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)amino)-4-ethoxycyclobut-3-ene-1,2-dione // Synonyms: N3-PEG3-NH-SQ-OEt, Azido-PEG3-Ethylsquaramide, SQ-PEG3-N3, N3-PEG3-Squarate
- Product code:RL-4420
- CAS No.:2920089-51-4
- Formula:C14H22N4O6
- Storage temperature:-20°C
- Molecular weight:342.35 g/mol
- Purity :min. 98.0%
from €90.00
description
A clickable PEG linker that can be reacted with amines and other nucleophiles.
This monoester amide has a high hydrolytic stability at alkaline pH making it superior bioconjugation tool when compared to conventional activated esters.
references
RAFT Polymer–Antibody Conjugation: Squaramide Ester Chemistry Leads to Conjugates with a Therapeutic Anti-EGFR Antibody with Full Retention of Activity and Increased Tumor Uptake In Vivo; A. Ardana, S. Ghosh, P. Huda, N. L. Fletcher, K. J. Thurecht, C. C. Williams; Mol. Pharmaceutics 2023; 20(6): 3073–3087. https://doi.org/10.1021/acs.molpharmaceut.3c00085
WO2023049963A1
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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