Prolines are key elements frequently positioned at the edge of β-turns in peptides. With modified prolines these positions can be used for either covalent amide or disulfide bonds – as has been demonstrated in many examples and publications – as we have demonstrated in many examples – or for filling hydrophobic pockets, whenever the pyrrolidine ring is substituted with groups like Methyl or Phenyl.

The following Proline building blocks are available, in order to design peptide structures, where hydrophobic interaction is increased.