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Amino Acids
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PotM: Furan-Crosslinking and 5HP2O as Maleimide Alternative
Game Changer for Protein Modification: Discover oxidation-induced furan crosslinking and 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones (5HP2Os) as stable alternative to maleimides.
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Chain Extension: Discover Homo Amino Acids
We expanded our portfolio of Fmoc-protected homo amino acids. Benefit of their unique properties to modulate the stability, hydrophobicity, and biological performance of your peptide!
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Hidden Champion – The Tetrahydropyranyl Protective Group
Tetrahydropyranyl (THP) is an excellent protective group for hydroxy and thiol moieties but rarely used in solid-phase peptide synthesis (SPPS). Discover its advantages, e.g., over O/StBu and Trt.
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Common Side Reactions in Fmoc Solid-Phase Peptide Synthesis
Collect information about the most common side reactions during Fmoc SPPS and how to avoid them! Choose your building blocks and conditions wisely to avoid unnecessary trouble!
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Bioisosteric Argininine Analogs
Same but different! Expand your possibilities for peptide modification and fine-tuning by implementing Nω-carbamoylated arginine building blocks as bioisosteric arginine analogs.
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Protecting Groups in SPPS
Mix & Match. Discover typically employed protecting groups used to temporarily mask reactive functional moieties during solid-phase peptide synthesis to prevent undesired side-reactions.
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Deprotection and Coupling in SPPS
Get the most out of your synthesis! Monitor your deprotection and coupling steps for completion and optimize your reaction protocols to maximize yields and minimize side-products!
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Boc versus Fmoc for Solid Phase Peptide Synthesis
Wondering about the difference between Boc and Fmoc chemistry in solid phase peptide synthesis? Don't worry: in this short overview we will guide you through the basics of both strategies.
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Norbornenes – Will You Click Me?
Proposing norbornenes – strained, bicyclic alkenes for fast, copper-free, biocompatible click-conjugation with tetrazines. Read on for more details on applications and available products!
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PotM: About the Impact of Fluorinated Building Blocks
Clever Move - Add positive effects to your molecule by introducing the most electronegative element. Discover fluorinated building blocks as game changer for your lead development.
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