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Publication
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Interview with C&EN
Our CSO and VP Business Development Dr. Thomas Bruckdorfer had the pleasure to talk to C&EN about our linkerology platform.
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Novel amino-Li resin for water-based solid-phase peptide synthesis
Amino-Li resin – a cross-linked polyacrylic amide solid support suitable for the synthesis of peptides and biomolecules, which is compatible with organic as well as aqueous solvents.
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Incorporation of pseudoproline monomer (Fmoc-Thr[ψMe,Mepro]–OH) facilitates efficient solid-phase synthesis of difficult peptides
Herein we investigate the incorporation of the Fmoc-Thr-pseudoproline monomer during Fmoc SPPS. Typically, pseudoprolines are incorporated as preformed dipeptides. However, the possibility of using the monomer adds flexibility to the synthesis.
Weiterlesen![Incorporation of pseudoproline monomer (Fmoc-Thr[ψMe,Mepro]–OH) facilitates efficient solid-phase synthesis of difficult peptides](https://cdn.iris-biotech.de/media//_cache/images/blog/610/Publikation_Dez2022.png)
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Solid-Phase Peptide Synthesis Using a Four-Dimensional (Safety-Catch) Protecting Group Scheme
As the molecular diversity of cyclic and branched peptides becomes more and more challenging, a high level of orthogonal dimensionality is required. Herein, we present a new category of orthogonal protecting groups.
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Solid-Phase Synthesis of an “Inaccessible” hGH-Derived Peptide Using a Pseudoproline Monomer and SIT-Protection for Cysteine
Herein, we report the first-time SPPS of a special peptide sequence via employment of of a serine pseudoproline building block as well as sec-isamyl mercaptan (SIT) as cysteine protecting group.
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2-Chlorotrityl Chloride and 4-Methylbenzhydryl Bromide Resin Loading Using the Mixture of Organic Solvents: A “Greener” Alternative to Dichloromethane and N,N-Dimethylformamide
Common protocols for the loading of 2-CTC and MBH-Br resins presume the application of DCM, THF, or DMF; these solvents are considered as undesirable in accordance with modern regulatory rules.
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Easy access to purified complex peptides on larger scales with the peptide easy clean technology – a liraglutide case study
With a remarkable amount of peptide therapeutics already on the market and many more to come, there is an ongoing need to improve manufacturing scale and efficiency for a sustainable, global supply.
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Innovative ways to fight SARS-CoV-2
With the approval of several COVID-19 vaccines and drugs in recent months, hope is growing that the current pandemic will end soon.
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Short arginine analogs: peptide synthesis prediction of biological effects
Arginine, a semi-essential amino acid, is involved in various important metabolic processes.
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