New: dPEG-Phospholipids for superior liposomes

Published on 17.06.2014

Novel liposomes built of dPEG-Phospholipids with defined PEG chain length provide prolonged blood-circulation time and improved cellular uptake as administration carriers for drugs, delivering active molecules to the desired target.

Liposomes made of conventional phospholipides have low bioavailability and blood-circulation time. Their performance can be improved significantly by the use of dPEG-Phospholipids (Poly(ethylene glycol)–distearoylphosphatidylethanolamine; PEG-DSPE). Those novel liposomes have clearly prolonged circulation time as administration carriers for drugs, delivering active molecules to the desired target^1,2. Due to PEG-DPSE’s amphiphilic characteristics and excellent biopcampatibility, it can as well be applied for polymeric nanoparticles, microemulsions, lipid polymer hybrid nanoparticles and solid lipid nanoparticles³.

Cellular uptake of PEG-DSPE liposomes can be improved significantly by using the right design elements such as the appropriate PEG-linker length in coordination with the appropriate liposomal PEG coating and optimal ligand density^4-6. Therefore we provide dPEG-Phospholipids with three different defined PEG lengths and additionally derivatives with MAL- or TFP-function for optimal drug loading.

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Jared F. Stefanick, Jonathan D. Ashley, and Basar Bilgicer, Enhanced Cellular Uptake of Peptide-Targeted Nanoparticles through IncreasedPeptide Hydrophilicity and Optimized Ethylene Glycol Peptide-Linker Length; ACSNano 2013; 7(9): 8115-8127; http://dx.doi.org/10.1021/nn4033954.
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