Eco-Friendly Combination of the Immobilized PGA Enzyme and the S-Phacm Protecting Group for the Synthesis of Cys-Containing Peptides

M. Góngora-Benítez, A. Basso, T. Bruckdorfer, M. Royo, J. Tulla, Puche, F. Albericio

Chem. Eur. J. 2012; 18: 16166-16176; https://doi.org/10.1002/chem.201201370

Abstract: Enzyme‐labile protecting groups have emerged as a green alternative to conventional protecting groups. These groups introduce a further orthogonal dimension and eco‐friendliness into protection schemes for the synthesis of complex polyfunctional organic molecules. S‐Phacm, a Cys‐protecting group, can be easily removed by the action of a covalently immobilized PGA enzyme under very mild conditions. Herein, the versatility and reliability of an eco‐friendly combination of the immobilized PGA enzyme and the S‐Phacm protecting group has been evaluated for the synthesis of diverse Cys‐containing peptides.