Peptide linkers are usually cleaved under acidic conditions or using two-step procedures. Photocleavage proceeds under neutral conditions using UV light and can either be performed in batch or using flow chemistry. Furthermore, photolabile linkers are orthogonal to standard peptide chemistry reaction conditions, thus enabling the use of a wide variety of amino acid protecting groups.

Two different photolabile linkers are available for your convenience:

• Photo-linker for the synthesis of C-terminal carboxylic acids
• Fmoc-amino photo-linker for the production of C-terminal carboxamides

→ Find more than 40 other linkers in our Linkers section!

References

• Continuous Photochemical Cleavage of Linkers for Solid-Phase Synthesis; M. Hurevich, J. Kandasamy, B. M. Ponnappa, M. Collot, D. Kopetzki, D. T. McQuade and P. H. Seeberger; Organic Letters 2014; 16: 1794-1797. doi:10.1021/ol500530q
• Photolytic Mass Laddering for Fast Characterization of Oligomers on Single Resin Beads; K. Burgess, C. I. Martinez, D. H. Russell, H. Shin and A. J. Zhang; The Journal of Organic Chemistry 1997; 62: 5662-5663. doi:10.1021/jo970866w
• Direct Monitoring of Organic Reactions on Polymeric Supports; M. R. Carrasco, M. C. Fitzgerald, Y. Oda and S. B. H. Kent; Tetrahedron letters 1997; 38: 6331-6334. doi:http://dx.doi.org/10.1016/S0040-4039(97)01456-1