Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying through a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.
Long-chain acylcarnitines are well-known intermediates in mitochondrial fatty acid oxidation
Long-chain acylcarnitines are well-known intermediates in mitochondrial fatty acid oxidation. Palmitoyl carnitine is a very potent specific inhibitor of protein kinase C (PKC), an important regulatory enzyme in several signal transduction cascades. Therefore, Palmitoyl carnitine has various physiological effects such as:
Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart.1
Is a protector against cardiomyopathy.2
Acts on voltage, current, and contraction in ventricular cells.3
Has a biphasic effects on the open probability of L-type Ca channels, causing an increase in activity immediately after the addition of L-PC, but leading to a decrease in open probability after a few minutes.4
Has an anti-proliferative anti-tumor effect.5,6
References:
Xiao C.Y. et al., Palmitoyl-L-carnitine modifies the myocardial levels of high-energy phosphates and free fatty acids. Basic Res. Cardiol. 1997; 92(5): 320-30.
Sayed-Ahmed M.M. et al., Propionyl-L-carnitine as protector against adriamycin-induced cardiomyopathy. Pharmacol. Res. 2001; 43(6): 513-20.
Shen J.B. and Pappano A.J., Palmitoyl-L-carnitine acts like ouabain on voltage, current, and contraction in guinea pig ventricular cells. Am. J. Physiol. 1995; 268: H1027-36.
Liu Q.Y. and Rosenberg R.L., Activation and inhibition of reconstituted cardiac L-type calcium channels by palmitoyl-L-carnitine. Biochem. Biophys. Res. Commun. 1996; 228: 252-8.
Nakadate T., Blumberg P.M., Modulation by palmitoylcarnitine of protein kinase C activation. Cancer Res. 1987; 47(24 Pt 1): 6537-42.
Vescovi G. et al., Modulation by palmitoyl-carnitine of calcium activated, phospholipid-dependent protein kinase activity and inhibition of melanoma cell growth. Br. J. Dermatol. 1988; 119(2): 171-8.
