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Herein we highlight products which we consider to be of special interest to our customers.
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PotM: Argpyrimidine Building Block for SPPS
Argpyrimidine is the result of a Maillard Reaction-like nonenzymatic posttranslational modification. You want to investigate the effect of this change on function and stability? Get the building block!
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PotM: CliCr® - an innovative click reagent
Herein, we present CliCr® as an innovative cyclic alkyne for metal-free strain-promoted click chemistry. Read our blog for detailed information about CliCr® reagents based on TMTHSI and check out available derivatives!
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PotM: His Tags for the Chemical Modification of Peptides
Jensen et al. developed two methods that use poly-His sequences to direct the highly selective acylation of proteins, either at the N-terminus or at a specific Lys residue. Read on for more information.
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PotM: Fmoc-Ser(Msbh)-OH
You are working on complex peptides and are looking for a new level of orthogonality facilitating the overall synthetic process and improving your yields? Check out the Msbh safety-catch protecting group!
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PotM: 1,4-Benzenedimethanethiol (BDMT)
1,4-Benzenedimethanethiol is used as thiol scavenger during solid-phase peptide synthesis. In comparison to other thiol scavengers, this reagent is odorless and provides high quality crude peptides.
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PotM: Smoc Amino Acids
Herein, we present the Clean Peptide Technology using Smoc Amino Acids developed by Sulfotools in Germany. Replace organic solvents with water during peptide synthesis - Read on for more information!
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PotM: Biotin – Desthiobiotin - Iminobiotin
Herein, we present 2-Iminobiotin, a cyclic guanidino analogue of biotin with pH-dependent affinity for avidin, and compare it to biotin and desthiobiotin. Click here for more detailed information.
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PotM: A Lysine Multitool Building Block
The para-azido benzyloxycarbonyl protected lysine building block Fmoc-L-Lys(4-N3-Z)-OH (FAA8830) is useful for a wide range of applications. Read on to find out more!
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PotM: Towards “Greener” Peptide Synthesis – Alternative Solvents for Loading of 2-CTC and 4-MBH-Br
Replace undesired solvents such as DCM, THF and DMF during the loading of 2-CTC and 4-MBH-Br resin by a “greener” EtOAc/MeCN (1:1) mixture. Click here and read on for more details.
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PotM: Proteolysis Targeting Chimeras (PROTACs®)
Drug the undruggable – click here to get more information about the use of PROteolysis TArgeting Chimeras (PROTACs®) as a tool for targeted protein degradation and discover available building blocks.
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