Spermines and other Biogenic Polyamines
interact due to their multi cationic structure with DNA!

Spermine(HHHN₃)*3HCl

1-Azido-5,10,14-triaza-tridecan
228,34*109,38 g/mole
C₁₀H₂₄N₆*3HCl

Code: SNN1170

Packing: 250mg, 1g, 5g

Find many other Spermines with different protecting groups at Iris Biotech – Spermine

Published Applications:

• Polyamines, like spermines and spermidines, stabilize nucleic acids against chemical and enzymatic degradation, facilitate the formation of secondary and tertiary structures and enhance cellular uptake.
  Andrew J. Marsh, David M. Williams and Jane A. Grasby;
  Organic & Biomolecular Chemistry 2004; 2: 2103 - 2112.

• Spermine participates in oxidative damage of guanosine and 8-oxoguanosine leading to deoxyribosylurea formation.
  M.E. Hosford, J.G. Muller, C.J. Burrows; J. Am. Chem. Soc. 2004; 126: 9540-9541.
  
  
• Structural Analysis of DNA Interactions with Biogenic Polyamines and Cobalt(III)hexamine Studied by Fourier Transform Infrared and Capillary Electrophoresis; Biogenic polyamines, such as putrescine and spermidine are involved in numerous diverse biological processes. Due to their binding to DNA and RNA they play an important role in nucleic acid function and cause DNA condensation and aggregation inducing DNA conformational changes.
  Amin Ahmed Ouameur and Heidar-Ali Tajmir-Riahi;
  J. Biol. Chem. 2004; 279(40): 42041-42054.