Name: ATFB
SKU: RL-2035
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250 mg

100,00 €

RL-2035.0250

500 mg

180,00 €

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RL-2035.0001

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description

Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet et al. as versatile photoaffinity labeling agents to probe biological receptors. Upon photolysis, N2 is liberated and a highly unstable singlet Phenylnitrene is being formed in situ, which reacts with neighboring molecules in a variety of reactions. Perfluorophenyl azides, however, form highly stabilized nitrene intermediates that undergo insertion and addition reactions in moderate to good yields rather than intermolecular rearrangements. This type of compounds has been used as photo-cross linker (Lamda max = 258nm) in estrogen receptor studies and for direct surface coating of carbon and organic based polymers.

references

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Li-Hong Liu, Mingdi Yan; Perfluorophenyl Azides: New Applications in Surface Functionalization and Nanomaterial Synthesis; Accounts of Chemical Research 2011; 43(11): 1434-1443.

DOI 10.1021/ar100066t.

Additional References:

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Keana, J.F.W., Cai, S.X.; J. Org. Chem. 1990; 55: 3640-3647.

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Kristof De Prijcka, Nele De Smetb, Monika Rymarczyk-Machalb, Gonzalez Van Driesschec, Bart Devreesec, Tom Coenyea, Etienne Schachtb & Hans J. Nelisa; Biofouling: The Journal of

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