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Boc-beta,beta-diMe-Phe-OH*DCHA (rac)
Chemical name: N-alpha-t-Butyloxycarbonyl-beta,beta-dimethyl-phenylalanine (rac.) dicyclohexylamine salt // Synonyms: 2-(tert-butoxycarbonylamino)-3-methyl-3-phenylbutanoic acid DCHA salt, (R,S)-Boc-2-amino-3-methyl-3-phenyl-butyric acid DCHA salt, (R,S)-Boc-beta,beta-dimethyl-phenylalaninedicyclohexylamine
- Product code:BAA2880
- CAS No.:144643-84-5 (net)
- Formula:C16H23NO4*C12H23N
from $118.75
description
beta,beta-Dimethylation of amino acids stabilizes appropriate peptides towards digestion by proteases.
references
Synthesis and Biological Activity of Analogues of the Antimicrotubule Agent N,beta,
beta-Trimethyl-L-phenylalanyl-N1-[(1S,2E )-3-carboxy-1-isopropylbut-2-enyl]-N1,3-dimethyl-L-valinamide (HTI-286);
A. Zask, G. Birnberg, K. Cheung, J. Kaplan, C. Niu, E. Norton, R. Suayan, A. Yamashita, D. Cole, Z. Tang, G. Krishnamurthy,
R. Williamson, G. Khafizova, S. Musto, R. Hernandez, T. Annable, X. Yang, C. Discafani, C. Beyer, L.M. Greenberger, F. Loganzo, S. Ayral-Kaloustian; J. Med. Chem. 2004; 47: 4774-4786.
Synthesis and Antimitotic/Cytotoxic Activity of Hemiasterlin Analogues; James A. Nieman, John E. Coleman, Debra J. Wallace, Edward Piers,Lynette Y. Lim, Michel Roberge, and Raymond J. Andersen; J. Nat. Prod. 2003; 66: 183-199. DOI: 10.1021/np020375t.
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