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Fmoc-Sieber-TG resin
Chemical name: Fmoc-Sieber-TentaGel resin // Synonyms: 9-(9-Fluorenylmethyloxycarbonylamino)-9H-xanthen-3-yl-oxymethyl TentaGel
- Product code:BR-2005
- Storage temperature:2-8°C
- Loading:0.15-0.3 mmol/g
from $225.00
description
Fmoc-Sieber amide resin is an acid-labile carrier for solid phase synthesis of peptide amides. Cleavage can be achieved with only 1% TFA in DCM making them an ideal carrier for the synthesis of protected peptide fragments in fragment condensation strategies for the synthesis of long peptides. It has also been used in organic synthesis of acid-sensitive compounds, for targeted synthesis of primary amines and N-alkylated secondary carboxyamides.
TentaGel resins consist of low cross-linked polystyrene on which poly(ethylene glycol) with a molecular weight of 3000 Da is grafted. The PEG spacer is attached to the polymer matrix via an ether bond, which shows high stability towards acid treatment and minimizes PEG leaching. The properties of TentaGel resins are dominated by PEG, which solubilizes both hydrophobic and hydrophilic compounds. TentaGel resins are pressure stable and can be used in batch processes as well as under continuous flow conditions.
references
Template-directed approach to solid-phase combinatorial synthesis of furan-based libraries; P. Gupta, S. K. Singh, A. Pathak and B. Kundu; Tetrahedron 2002; 58: 10469-10474. https://doi.org/10.1016/s0040-4020(02)01396-0
Multiple solid phase synthesis of (RS)-1-aminophosphinic acids; E. A. Boyd, W. C. Chan and V. M. Loh; Tetrahedron Letters 1996; 37: 1647-1650. https://doi.org/10.1016/0040-4039(96)00082-2
Reductive alkylation of 9-amino-xanthen-3-yloxymethylpoly(styrene): a novel procedure for the synthesis of peptidyl N-alkyl amides by Fmoc/But chemistry; W. C. Chan and S. L. Mellor; Journal of the Chemical Society, Chemical Communications 1995: 1475-1477. https://doi.org/10.1039/c39950001475
Facile synthesis of protected C-terminal peptide segments by Fmoc/But solid-phase procedures on N-Fmoc-9-amino-xanthen-3-yloxymethyl polystyrene resin; W. C. Chan, P. D. White, J. Beythien and R. Steinauer; Journal of the Chemical Society, Chemical Communications 1995: 589-592. https://doi.org/10.1039/c39950000589
A new acid-labile anchor group for the solid-phase synthesis of C-terminal peptide amides by the Fmoc method; P. Sieber; Tetrahedron Letters 1987; 28: 2107-2110. https://doi.org/10.1016/s0040-4039(00)96055-6
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