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Ramage Resin
Chemical name: 2-(5-(9-Fluorenylmethyloxycarbonyl)amino-10,11-dihydro-5H-dibenzo[a,d]cycloheptenyl-2-oxy)actamido polystyrene // Synonyms: DCHD Resin, Ramage Amide AM Resin
- Product code:BR-5204
- Storage temperature:2-8°C
- Particle size :100-200 mesh
- DVB crosslinking :1% DVB
- Loading:0.3-1.5 mmol/g
from $212.50
description
Alternative to the commonly used Rink-resin. The three-circular structure of the Ramage linker prevents fragmentation of the linker during cleavage from the resin followed by back alkylation. A common phenomenon observed during peptide synthesis with the open structure of the Rink-amide linker. Hence, Ramage linker delivers peptides with higher purity and less impurities, than peptides produced with the Rink-amide linker. Ramage resin is particularly recommended for C-terminal Phe, Tyr and Ile. Following Fmoc removal, the resin can be acylated under standard conditions with Fmoc/tBu protocols. Peptide amides can be released from the resin with 50% TFA in DCM or 95% aqueous TFA.
references
Potassium channel modulation by a toxin domain in matrix metalloprotease 23; S. Rangaraju, K. K. Khoo, Z. P. Feng, G. Crossley, D. Nugent, I. Khaytin, V. Chi, C. Pham, P. Calabresi, M. W. Pennington, R. S. Norton and K. G. Chandy; J Biol Chem 2010; 285: 9124-36. https://doi.org/10.1074/jbc.M109.071266
An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii; R. V. Baudinette, P. Boontheung, I. F. Musgrave, P. A. Wabnitz, V. M. Maselli, J. Skinner, P. F. Alewood, C. S. Brinkworth and J. H. Bowie; FEBS J 2005; 272: 433-43. https://doi.org/10.1111/j.1742-4658.2004.04483.x
Evaluation of some fluorogenic substrates for continuous assay of aminopeptidase P; S. J. Hawthorne, P. Harriott, J. Lim, A. J. Turner, B. Walker and C. H. Williams; Anal Biochem 1997; 253: 13-7. https://doi.org/10.1006/abio.1997.2320
Design of a versatile linker for solid phase peptide synthesis: Synthesis of C-terminal primary/seconary amides and hydrazides; R. Ramage, S. L. Irving and C. McInnes; Tetrahedron Letters 1993; 34: 6599-6602. https://doi.org/10.1016/0040-4039(93)88115-y
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