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Fmoc-NHNH-2CT Resin
Chemical name: Fmoc-hydrazine-2-chlorotrityl resin // Synonyms: Fmoc-NHNH-Trt(2-Cl) Resin, Fmoc-hydrazine-Trt(2-Cl) Resin
- Product code:BR-5279
- Particle size :100-200 mesh
- DVB crosslinking :1% DVB
- Loading:0,4-1,4 mmol/g
from $887.50
description
This resin can be used for the synthesis of peptide hydrazides. Peptide hydrazides can be converted to thioesters, which serve as substrates for native chemical ligation (NCL). Preloaded derivatives can be provided based on custom synthesis.
references
A shelf stable Fmoc hydrazine resin for the synthesis of peptide hydrazides; M. J. Bird, P. E. Dawson; Pept. Sci. 2022; 114(5): e24268. https://doi.org/10.1002/pep2.24268
Facile synthesis of C-terminal peptide hydrazide and thioester of NY-ESO-1 (A39-A68) from an Fmoc-hydrazine 2-chlorotrityl chloride resin; Y. Huang, C. Chen, S.-J. Li, S. Gao, J. Shi, Y.-M. Li; Tetrahedon 2014; 70(18): 2951-2955. https://doi.org/10.1016/j.tet.2014.03.022
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