Fmoc-NHNH-2CT Resin

Chemical name: Fmoc-hydrazine-2-chlorotrityl resin // Synonyms: Fmoc-NHNH-Trt(2-Cl) Resin, Fmoc-hydrazine-Trt(2-Cl) Resin

  • Product code:BR-5279
  • Storage temperature:-20°C
  • Particle size :100-200 mesh
  • DVB crosslinking :1% DVB
  • Loading:0,4-1,4 mmol/g

from $887.50

Grouped product items
Qty Packing unit Price SKU Availability
1 g
$887.50
BR-5279.0001
11-20 business days
5 g
$2,037.50
BR-5279.0005
11-20 business days
Safety Data Sheets
description

This resin can be used for the synthesis of peptide hydrazides. Peptide hydrazides can be converted to thioesters, which serve as substrates for native chemical ligation (NCL). Preloaded derivatives can be provided based on custom synthesis.

references

A shelf stable Fmoc hydrazine resin for the synthesis of peptide hydrazides; M. J. Bird, P. E. Dawson; Pept. Sci. 2022; 114(5): e24268. https://doi.org/10.1002/pep2.24268


Facile synthesis of C-terminal peptide hydrazide and thioester of NY-ESO-1 (A39-A68) from an Fmoc-hydrazine 2-chlorotrityl chloride resin; Y. Huang, C. Chen, S.-J. Li, S. Gao, J. Shi, Y.-M. Li; Tetrahedon 2014; 70(18): 2951-2955. https://doi.org/10.1016/j.tet.2014.03.022

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