Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-3-chloro-L-alanine // Synonyms: (R)-2-[(9-Fluorenylmethyloxycarbonyl)amino]-3-chloro-propionic acid, Fmoc-beta-chloro-L-alanine, Fmoc-3-chloro-L-alanine, Fmoc-Ala(3-Cl)-OH

  • Product code:FAA3170
  • CAS No.:212651-52-0
  • Formula:C18H16ClNO4
  • Molecular weight:345.78 g/mol
  • Purity :min. 98%
  • Enantiomeric Purity:min. 99,7%

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1 g
5 g
25 g

The Chlorine function in this building block is labile and reactive. Depending on reaction conditions, it is prone to nucleophilic substitution or to elimination. Thus, it is not primarily a building block to permanently introduce 3-Chloroalanine into a peptide, but rather to use the function for further modification such as cyclic peptide ring closure or introduction of Dehydroalanine. However, there are also publications (see below) reporting introduction of 3-Chloroalanine into peptides without elimination.


Halogen Bonding: A Powerful Tool for Modulation of Peptide Conformation; E. Danelius, H. Andersson, P. Jarvoll, K. Lood, J. Gräfenstein, M. Erdélyi; Biochemistry 2017; 56: 3265-3272.

Cyclization of Peptides by using Selenolanthionine Bridges; A. D. de Araujo, M. Mobli, G. F. King, P. F. Alewood; Angew. Chem. Int. Ed. 2012; 51: 10298-10302.

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