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Fmoc-L-Arg(Me,Pbf)-OH
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-N'-methyl-N''-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine // Synonyms: Fmoc-Arg(Me)(Pbf)-OH, Fmoc-N-omega-methyl-L-arginine(Pbf), Fmoc-Arg(Me,Pbf)-OH
- Product code:FAA3360
- CAS No.:1135616-49-7
- Formula:C35H42N4O7S
- Storage temperature:2-8°C
- Molecular weight:662.8 g/mol
from $187.50
description
Arg(Me) can be introduced in peptide sequences by conventional Fmoc/tBu SPPS using this derivative. N-omega-Methylation is a widespread post-translational modification of Arg-containing proteins.
references
Rational Design and Synthesis of Modified Teixobactin Analogues: In Vitro Antibacterial Activity against Staphylococcus aureus, Propionibacterium acnes and Pseudomonas aeruginosa; V. Ng, S. A. Kuehne and W. C. Chan; Chemistry 2018; 24: 9136-9147. doi: https://doi.org/10.1002/chem.201801423
Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction; H. Karatas, Y. Li, L. Liu, J. Ji, S. Lee, Y. Chen, J. Yang, L. Huang, D. Bernard, J. Xu, E. C. Townsend, F. Cao, X. Ran, X. Li, B. Wen, D. Sun, J. A. Stuckey, M. Lei, Y. Dou and S. Wang; Journal of medicinal chemistry 2017; 60: 4818-4839. doi: https://doi.org/10.1021/acs.jmedchem.6b01796
Iterative conversion of cyclin binding groove peptides into druglike CDK inhibitors with antitumor activity; P. N. Premnath, S. N. Craig, S. Liu, E. L. Anderson, A. I. Grigoroudis, G. Kontopidis, T. L. Perkins, M. D. Wyatt, D. L. Pittman and C. McInnes; Journal of medicinal chemistry 2015; 58: 433-42. doi: https://doi.org/10.1021/jm5015023
Effect of arginine methylation on the RNA recognition and cellular uptake of Tat-derived peptides; J. H. Li, W. C. Chiu, Y. C. Yao and R. P. Cheng; Bioorg Med Chem 2015; 23: 2281-6. doi: https://doi.org/10.1016/j.bmc.2015.01.051
Trypsin resistance of a decapeptide KISS1R agonist containing an Nomega-methylarginine substitution; T. Asami, N. Nishizawa, Y. Ishibashi, K. Nishibori, Y. Horikoshi, H. Matsumoto, T. Ohtaki and C. Kitada; Bioorg Med Chem Lett 2012; 22: 6328-32. doi: https://doi.org/10.1016/j.bmcl.2012.08.087
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