Fmoc-L-Agb-OH*HCl

Chemical name: (S)-N-alpha-(9-Fluorenylmethyloxycarbonyl)-2-amino-4-guanidino-butyric acid hydrochloride // Synonyms: (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-(diaminomethyleneamino)butanoic acid, 2-(Fmoc-amino)-4-guanidino-L-butyric acid, Fmoc-Agb-OH*HCl, Fmoc-L-Nar*HCl,Fmoc-L-norArg*HCl, Fmoc-Nar*HCl, Fm oc-L-Norarginine hydrochloride

  • Product code:FAA7670
  • CAS No.:1070777-24-0 net
  • Formula:C20H22N4O4*HCl
  • Storage temperature:2-8°C
  • Molecular weight:382.41*36.45 g/mol
  • Purity :min. 99%
  • Enantiomeric Purity:min. 99,7%

from $112.50

Grouped product items
Qty Packing unit Price SKU Availability
250 mg
$112.50
FAA7670.0250
<10 business days
500 mg
$168.75
FAA7670.0500
<10 business days
1 g
$262.50
FAA7670.1000
<10 business days
5 g
$937.50
FAA7670.5000
Please inquire
description

Used as a protected Arginine homologue in peptide synthesis. The guanidino-group is protected by protonation, which can be restored after Fmoc-cleavage by pre-washing of the peptide with pyridine hydrobromide (0.08M in DMF) for 10min. prior to the next coupling.

references

Trypsin resistance of a decapeptide KISS1R agonist containing an Nù-methylarginine substitution.

Asami T., Nishizawa N., Ishibashi Y., Nishibori K., Horikoshi Y., Matsumoto H., Ohtaki T., Kitada C.; Bioorg Med Chem Lett. 2012; 22(20): 6328-6332. DOI: 10.1016/j.bmcl.2012.08.087.

Peptide Macrocycle Inhibitor of Coagulation Factor XII with Subnanomolar Affinity and High Target Selectivity; Simon J. Middendorp, Jonas Wilbs, Claudia Quarroz, Sara Calzavarini, Anne Angelillo-Scherrer, Christian Heinis; J. Med. Chem. 2017; 60(3): 1151-1158. DOI: 10.1021/acs.jmedchem.6b01548;

Design, Synthesis, Molecular Dynamics Simulation, and Functional Evaluation of a Novel Series of 26RFa Peptide Analogues Containing a Mono- or Polyalkyl Guanidino Arginine Derivative; Karima Alim, Benjamin Lefranc, Jana Sopkova-de Oliveira Santos, Christophe Dubessy, Marie Picot, Jean A. Boutin, Hubert Vaudry, Nicolas Chartrel, David Vaudry, Julien Chuquet, Jérôme Leprince; J. Med. Chem. 2018; 61(22): 10185-10197. DOI: 10.1021/acs.jmedchem.8b01332.


Do you need further information about this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!