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Fmoc-L-Asp(OMpe)-OH
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-aspartic acid beta-3-methylpentyl ester // Synonyms: Fmoc-Asp(OMpe)-OH, N-alpha-Fmoc-(O-3-methyl-pent-3-yl)aspartic acid, (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-((3-methylpentan-3-yl)oxy)-4-oxobutanoic acid,Fmoc-Asp(OMpe)-OH
- Product code:FAA8120
- CAS No.:180675-08-5
- Formula:C25H29NO6
- Molecular weight:439.51 g/mol
from $156.25
description
An excellent derivative for minimizing aspartimide formation during Fmoc SPPS of Asp-containing peptides. The bulky OMpe protecting group provides considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu group.
references
A new protecting group for aspartic acid that minimizes piperidine-catalyzed aspartimide formation in Fmoc solid phase peptide synthesis. Amelie Karlström, Anders Undén; Tetrahedron Lett. 1996; 37(24): 4243-4246. DOI: 10.1016/0040-4039(96)00807-6
The aspartimide problem in Fmoc‐based SPPS. Part II. M. Mergler, F. Dick, B. Sax, C. Stähelin, T. Vorherr; J. Pept. Sci. 2003; 9(8): 518-526. DOI: 10.1002/psc.473
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