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Fmoc-L-HfVal-OH
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-4,4,4,4’,4’,4’-hexafluoro-L-valine // Synonyms: (S)-Fmoc-2-amino-4,4,4-trifluoro-3-(trifluoromethyl)butanoic acid, Fmoc-L-4,4,4,4',4',4'-hexafluororvaline,(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4,4,4-trifluoro-3-(trifluoromethyl)butanoi c acid, Fmoc-HfVal-OH
- Product code:FAA8320
- CAS No.:1212153-68-8
- Formula:C20H15F6NO4
- Molecular weight:447.33 g/mol
from $3,750.00
references
Stereoselective Synthesis of [5-[4,4,4,4’,4’,4’-Hexafluoro-N-(2-hydroxyethoxy)-D-valine]]- and [5-[4,4,4,4’,4’,4’-Hexafluoro-N-(2-hydroxyethoxy)-L-valine]cyclosporin A; M. K. Eberle and R. Keese; Helvetica Chimica Acta 2010; 93: 1583-1601. https://doi.org/10.1002/hlca.201000175
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease; S. C. Mayer, A. F. Kreft, B. Harrison, M. Abou-Gharbia, M. Antane, S. Aschmies, K. Atchison, M. Chlenov, D. C. Cole, T. Comery, G. Diamantidis, J. Ellingboe, K. Fan, R. Galante, C. Gonzales, D. M. Ho, M. E. Hoke, Y. Hu, D. Huryn, U. Jain, M. Jin, K. Kremer, D. Kubrak, M. Lin, P. Lu, R. Magolda, R. Martone, W. Moore, A. Oganesian, M. N. Pangalos, A. Porte, P. Reinhart, L. Resnick, D. R. Riddell, J. Sonnenberg-Reines, J. R. Stock, S. C. Sun, E. Wagner, T. Wang, K. Woller, Z. Xu, M. M. Zaleska, J. Zeldis, M. Zhang, H. Zhou and J. S. Jacobsen; Journal of medicinal chemistry 2008; 51: 7348-51. https://doi.org/10.1021/jm801252w
Synthesis of [Hexafluorovalyl1,1’]gramicidin S; T. Arai, T. Imachi, T. Kato, H. I. Ogawa, T. Fujimoto and N. Nishino; Bulletin of the Chemical Society of Japan 1996; 69: 1383-1389. https://doi.org/10.1246/bcsj.69.1383
Long-acting angiotensin II inhibitors containing hexafluorovaline in position 8; K. H. Hsieh, P. Needleman and G. R. Marshall; Journal of medicinal chemistry 1987; 30: 1097-100. https://doi.org/10.1021/jm00389a021
Synthesis of fluorine-containing peptides. Analogues of angiotensin II containing hexafluorovaline; W. H. Vine, K. H. Hsieh and G. R. Marshall; Journal of medicinal chemistry 1981; 24: 1043-7. https://doi.org/10.1021/jm00141a005
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