Fmoc-L-Sec(Mob)-OPfp

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-4-methoxybenzyl selenocysteine pentafluorophenyl ester // Synonyms: Fmoc-L-Sec(pMeOBzl)-OPfp, Fmoc-Sec(MBzl)-OPfp, Fmoc-L-Sec(Pmb)-OPfp, Fmoc-Sec(Mob)-OPfp, Fmoc-L-4-methoxybenzyl selenocysteine pentafluorophenyl ester, 2,3,4,5,6-pentafluorophenyl(2R)-2-({[(9H-fluor en-9-yl)methoxy]carbonyl}amino)-3-{[(4-methoxyphen

  • Product code:FAA8760
  • CAS No.:939431-43-3
  • Formula:C32H24F5NO5Se
  • Molecular weight:676.51 g/mol
  • Purity :min. 98%
  • Enantiomeric Purity:min. 99,7%

from $202.50

Grouped product items
Qty Packing unit Price SKU Availability
100 mg
$202.50
FAA8760.0100
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250 mg
$337.50
FAA8760.0250
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500 mg
$607.50
FAA8760.0500
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1 g
$945.00
FAA8760.1000
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5 g
$3,375.00
FAA8760.5000
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description

Isomeric purity >99.9%. Building block for the introduction of selenocysteine by SPPS. Peptides containing selenocysteine can be cleaved from the resin with simultaneous side-chain deprotection by treatment with 5% (v/v) water, 95% (v/v) trifluoroacetic acid (TFA), 0.4 M 2,2’-dithiobis(5-nitropyridine) (DTNP) for 7 min at 60 °C or 2 h at RT.


references

References:

Selenocysteine-Mediated Native Chemical Ligation; R. Quaderer, A. Sewing, D. Hilvert; Helv. Chim. Acta 2001; 84(5): 1197-1206; https://doi.org/10.1002/1522-2675(20010516)84:5<1197::AID-HLCA1197>3.0.CO;2-%23.


Selenoglutathione: Efficient Oxidative Protein Folding by a Diselenide; J. Beld, K. J. Woycechowsky, D. Hilvert; Biochemistry 2007; 46(18): 5382-5390. https://doi.org/10.1021/bi700124p.

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