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Fmoc-(Sar)7-OH
Chemical name: 1-(9H-fluoren-9-yl)-4,7,10,13,16,19,22-heptamethyl-3,6,9,12,15,18,21-heptaoxo-2-oxa-4,7,10,13,16,19,22-heptaazatetracosan-24-oic acid // Synonyms: Fmoc-(Sar)7, Fmoc-heptasarcosine, Fmoc-(Sar)7-OH, Fmoc-Sar-Sar-Sar-Sar-Sar-Sar-Sar-OH
- Product code:FAA9255
- Formula:C36H47N7O10
- Storage temperature:2-8°C
- Molecular weight:737.81 g/mol
- Purity :min. 98,0%
from $137.50
description
Used as a monodisperse poly-Sarcosine linker/building-block in solution-phase and solid-phase peptide synthesis.
references
WO 2019081455 A1
Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform; L. Conilh, G. Fournet, E. Fourmaux, A. Murcia, E.-L. Matera, B. Joseph, C. Dumontet, W. Viricel; Pharmaceuticals 2021, 14(3): 247. https://doi.org/10.3390/ph14030247
Patents by Bicycle Therapeutics:
WO2021250418A1
WO2019193328A1
WO2013050617A1
US20220135614A1
WO2019162682A1
Patents and publications by Biontech:
WO2021191265A1
Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery; S. S. Nogueira, A. Schlegel, K. Maxeiner, B. Weber, M. Barz, M. A. Schroer, C. E. Blanchet, D. I. Svergun, S. Ramishetti, D. Peer, P. Langguth, U. Sahin, H. Haas; ACS Appl. Nano Mater. 2020, 3(11): 10634–10645. https://doi.org/10.1021/acsanm.0c01834
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