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Fmoc-L-3-(2-cyano-4-pyridyl)-alanine
Chemical name: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-cyanopyridin-4-yl)propanoic acid // Synonyms: (S)-Fmoc-2-amino-3-(2-cyanopyridin-4-yl)propanoic acid
- Product code:FAA9370
- CAS No.:2245755-79-5
- Formula:C24H19N3O4
- Storage temperature:-20°C
- Molecular weight:413.43 g/mol
from $500.00
references
Synthesis of DNA-Encoded Macrocyclic Peptides via Nitrile-Aminothiol Click Reaction; L. Fan, Y. Yu, C. Jayne, J. R: frost, J. D. Scott; Org. Lett 2023; 25(44): 8038-8042. https://doi.org/10.1021/acs.orglett.3c03284
Enabling Genetic Code Expansion and Peptide Macrocyclization in mRNA Display via a Promiscuous Orthogonal Aminoacyl-tRNA Synthetase; S. E. Iskandar, J. M. Pelton, E. T. Wick, D. L. Bolhuis, A. S. Baldwin, M. J. Emanuele, N. G. Brown, A. A. Bowers; J. Am. Chem. Soc. 2023; 145(3): 1512-1517. https://doi.org/10.1021/jacs.2c11294
Selective thiazoline peptide cyclisation compatible with mRNA display and efficient synthesis; M. Liu, R. Morewood, R. Yoshisada, M. N. Pascha, A. J. P. Hopstaken, E. Tarcoveanu, D. A. Poole, C. A. M. de Haan, C. Nitsche, S. A. K. Jongkees; Chem. Sci. 2023; 14(38): 10561-10569. https://doi.org/10.1039/D3SC03117A
Genetic Encoding of Cyanopyridylalanine for In-Cell Protein Macrocyclization by the Nitrile-Aminothiol Click Reaction; E. H. Abdelkader, H. Qianzhu, J. George, R. Frkic, C. J. Jackson, C. Nitsche, G. Otting, T. Huber; Angew. Chem. Int. Ed. 2022; 61(13): e202114154. https://doi.org/10.1002/anie.202114154
Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors; S. Ullrich, V. M. sasi, M. C. Mahawaththa, K. B. Ekanayake, R. Morewood, J. George, L. Shuttleworth, X. Zhang, C. Withefield, G. Otting, C. Jackson, C. Nitsche; Bioorg. Med. Chem. Lett. 2021; 50: 128333. https://doi.org/10.1016/j.bmcl.2021.128333
Biocompatible Macrocyclization between Cysteine and 2‑Cyanopyridine Generates Stable Peptide Inhibitors; C. Nitsche, H. Onagi, J.-P. Quek, G. Otting, D. Luo, T. Huber; Org. Lett. 2019; 21(22): 4709-4712. https://doi.org/10.1021/acs.orglett.9b01545
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