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H-Gly-L-Arg-pNA*2HCl
Chemical name: Glycyl-L-arginine p-nitroanilide dihydrochloride // Synonyms: H-Gly-Arg-pNA*2HCl
- Product code:HAA2755
- CAS No.:103192-40-1 net
- Formula:C14H21N7O4*2HCl
- Storage temperature:2-8°C
- Molecular weight:351.36*72.9 g/mol
- Purity :min. 98%
- Enantiomeric Purity:min. 99.7%
from $150.00
description
Gly-L-Arg-pNA is a chromgenic substrate for Dipeptiylpeptidase I (DPP I; cathepsin C) and DPP II or P. gingivalis dipeptidyl peptidase. It can furthermore be used as building block for test substrates for Coagulation Factor Xa and XIIa, t-Plasminogen Activator (tPAS) and u-Plasminogen Activator (uPA), Envelysin, C1 Esterase Inhibitor, Trypsin, Matriptase, horseshoe crab clotting enzyme and many others.
references
1. Dipeptidyl peptidase with strict substrate specificity of an anaerobic periodontopathogen Porphyromonas gingivalis; S. Fujimura, K. Hirai and Y. Shibata; FEMS Microbiol Lett 2002; 209: 127-31.
2. The preparation and properties of immobilised dipeptidyl-aminopeptidase I (cathepsin C); D. W. Hutchinson and A. Tunnicliffe; Biochim Biophys Acta 1987; 916: 1-4.
3. Human tissue factor pathway inhibitor fused to CD4 binds both FXa and TF/FVIIa at the cell surface; K. Riesbeck, A. Dorling, G. Kemball-Cook, J. H. McVey, M. Jones, E. G. Tuddenham and R. I. Lechler; Thromb Haemost 1997; 78: 1488-94.
4. Physiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop; K. Sichler, E. Kopetzki, R. Huber, W. Bode, K. P. Hopfner and H. Brandstetter; J Biol Chem 2003; 278: 4121-6.
5. Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors; M. Renatus, W. Bode, R. Huber, J. Sturzebecher, D. Prasa, S. Fischer, U. Kohnert and M. T. Stubbs; J Biol Chem 1997; 272: 21713-9.
6. Current diagnostic possibilities in hereditary angioedema and acquired angioedema; W. Dick and W. Cullmann; Immun Infekt 1985; 13: 113-8.
7. Chromogenic substrates for horseshoe crab clotting enzyme. Its application for the assay of bacterial endotoxins; S. Iwanaga, T. Morita, T. Harada, S. Nakamura, M. Niwa, K. Takada, T. Kimura and S. Sakakibara; Haemostasis 1978; 7: 183-8.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
