Ac-LRSR-Rh110-p TFA salt

Chemical name: N-Acetyl-leucyl-arginyl-seryl-arginyl-Rh110-D-proline TFA salt // Synonyms: Ac-Leu-Arg-Ser-Arg-Rhodamine(110)-D-Pro, substrate for MALT1

  • Product code:LS-3560
  • Formula:C48H63N13O10
  • Molecular weight:982.09 g/mol

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1 mg
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LS-3560.0001
description

This asymmetric Rhodamine 110 substrates for MALT1 employs a simple and straight forward kinetics upon analysis. Absorption wave length 492 nm, emission wave length 529 nm. While the intact substrate is virtually non-fluorescent, fluorescence largely increases (approx.. 3500 fold) upon cleavage. Superior signal-to-noise ratio combined with high sensitivity. In Rh110 assays this substrate delivers much less false positive hits in synthetic product libraries than corresponding AMC (7-amino-4-methylcoumarin) substrates.

references

Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin; Farid El Oualid, Remco Merkx, Reggy Ekkebus, Dharjath S. Hameed, Judith J. Smit, Annemieke de Jong, Henk Hilkmann, Titia K. Sixma, and Huib Ovaa; Angew. Chem. Int. Ed. 2010; 49: 10149 -10153. DOI: 10.1002/anie.201005995.

C. Wiesmann et al.; J. Mol. Biol. 2012; 419: 4-21.

S.K. Grant et al.; J. Biomol. Screen. 2002; 7(6): 531-540.

U. Hassiepen et al.; Anal. Biochem. 2007; 371: 201-207.

S.P. Leytus et al.; Biochem. J. 1983; 209: 299-307.

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