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I-PEG-alkyne (20 kDa)
Chemical name: alpha-Iodo-omega-propargylacetamido poly(ethylene glycol) // Synonyms: I-PEG(20 kDa)-alkyne
- Product code:PEG3100
- Storage temperature:-20°C
- Molecular weight:20000 Da
from $425.00
description
In conjugation techniques with thiol groups from Cystein or other SH carrying moieties normally maleimides are used, which react also with other acid protons like for example from OH or NH2 and give appropriate unwanted impurities. The Iodo group reacts much more specifically with thiol resulting in much cleaner conjugates.
references
Quantitative reactivity profiling predicts functional cysteins in proteomes; K.Weerapana, C.Wang, G.M.Simon, F.Richter, S.Khare, M.B.D.Dillon, D.A.Bachovichin, K.Mowen, D.Baker,
B.J.Cravatt; Nature 2010; 468: 790-795.
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