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HO-PEG-SQA (5 kDa)
Chemical name: alpha-Hydroxy-omega-squaric acid ethyl ester poly(ethylene glycol) // Synonyms: HO-PEG(5 kDa)-SQA
- Product code:PEG6615
- CAS No.:1421319-95-0
- Storage temperature:-20°C
- Molecular weight:5000 Da
from $637.50
description
PEGylating reagent with squaric acid ethyl ester, which reacts chemoselectively with amino functions of lysine in proteins. Guanidine functions of arginines, hydroxy groups of serine and threonine and imidazoles from histidines are not affected.
references
Squaric Acid Mediated Chemoselective PEGylation of Proteins: Reactivity of Single-Step-Activated á-Amino Poly(ethylene glycol)s; Carsten Dingels, Frederik Wurm, Manfred Wagner, Harm-Anton Klok, Holger Frey;
Chem. Eur. J. 2012; 18(52): 16828-16835. DOI: 10.1002/chem.201200182.
Synthetic Vaccines Consisting of Tumor-Associated MUC1 Glycopeptide Antigens and a T-Cell Epitope for the Induction of a Highly Specific Humoral Immune Response; Ulrika Westerlind, Alexandra Hobel, Nikola Gaidzik, Edgar Schmitt, Horst Kunz; Angew Chem Int Ed 2008; 47: 7551-7556. DOI: 10.1002/anie.200802102.
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