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Fmoc-L-Thr(MeO-BH resin)-NH2
Chemical name: Fmoc-L-Threonine alpha-amide-O-(4-methoxybenzhydryl resin) // Synonyms: Fmoc-Thr(MeO-BH resin)-NH2
- Product code:RAA2680
- Particle size :100-200 mesh
- DVB crosslinking :1% DVB
- Loading:ca. 0.5 mmol/g
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description
Very acid labile resin, which enables synthesis of peptide amides without the use of amide linkers (Rink, Ramage, Sieber, etc.)
Peptides can be cleaved as protected fragments, which enables very easy in-process control of the success and completion of any coupling step.
references
K. Barlos et all. WO 2013/098802 A2.
K. Barlos, D. Gatos et all., Int. J. Peptide and Protein Res. 1991; 38: 555-561.
K. Barlos and D. Gatos, in Fmoc solid phase peptide synthesis, edit. W.C. Chan and P. D. White, Oxford University Press, 2000.
Attachment of Histidine, Histamine and Urocanic acid to Resins of the Trityl-Type. Eleftheriou, S.; Gatos, D.; Panagopoulos, A.; Stathopoulos, S.; Barlos, K.; Tetrahedron Letters
1999; 40(14): 2825-2828.
G. Sabatino et all, Tetrahedron Letters 1999; 40: 809-812.
E. Atherton et. all. US 7,691,968 B2.
F. Albericio et. all WO 2008/040536 A1.
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