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Mal-CH2CH2-N-(CH2-COOH)2
Chemical name: 2,2'-((2-(maleinimido)ethyl)azanediyl)diacetic acid // Synonyms: 2,2'-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)azanediyl)diacetic acid
- Product code:RL-3450
- CAS No.:207612-92-8
- Formula:C10H12N2O6
- Molecular weight:256.21 g/mol
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references
Facile synthesis of maleimide bifunctional linkers. H. Dalton King, Gene M. Dubowchik, Michael A. Walker; Tetrahedron Lett 2002; 43(11): 1987-1990. DOI: 10.1016/S0040-4039(02)00192-2
Doxorubicin immunoconjugates containing bivalent, lysosomally-Cleavable dipeptide linkages. Gene M. Dubowchik, Shilpa Radia, Harold Mastalerz, Michael A. Walker, Raymond A. Firestone, H. Dalton King, Sandra J. Hofstead, David Willner, Shirley J. Lasch, Pamela A. Trail; Bioorg. Med. Chem. Lett. 2002; 12(11): 1529-1532. DOI: 10.1016/S0960-894X(02)00194-4
Long-Term Stabilization of Maleimide–Thiol Conjugates. Shaun D. Fontaine, Ralph Reid, Louise Robinson, Gary W. Ashley, Daniel V. Santi; Bioconjugate Chem. 2015; 26(1): 145-152. DOI: 10.1021/bc5005262
Mild Method for Succinimide Hydrolysis on ADCs: Impact on ADC Potency, Stability, Exposure, and Efficacy. L. Nathan Tumey, Manoj Charati, Tao He, Eric Sousa, Dangshe Ma, Xiaogang Han, Tracey Clark, Jeff Casavant, Frank Loganzo, Frank Barletta, Judy Lucas, Edmund I. Graziani; Bioconjugate Chem. 2014; 25(10): 1871-1880. DOI: 10.1021/bc500357n
Covalent Modification of Biomolecules through Maleimide-Based Labeling Strategies. Kévin Renault, Jean Wilfried Fredy, Pierre-Yves Renard, Cyrille Sabot; Bioconjugate Chem. 2018; 29(8): 2497-2513. DOI: 10.1021/acs.bioconjchem.8b00252
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