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Fmoc-AEEP-DMB
Chemical name: (9-Fluorenylmethyloxycarbonyl)amino-PEG(2)-Dtpp // Synonyms: (9H-fluoren-9-yl)methyl N-(2-{2-[3-(1,3-dimethyl-2,4,6-trioxo-1,3-diazinan-5-ylidene)-3-hydroxypropoxy]ethoxy}ethyl)carbamate, (9H-fluoren-9-yl)methyl(2-(2-(3-(1,3-dimethyl-2,4,6-trioxotetrahydropyr imidin-5(2H)-ylidene)-3-hydroxypropoxy)ethoxy)ethy
- Product code:RL-3470
- Formula:C28H31N3O8
- Molecular weight:537.57 g/mol
- Purity :min. 99%
from $150.00
description
Fmoc-AEEP-DMB is used as a solubility-enhancing linker in the “helping hand” strategy for purification of highly insoluble peptides. Several Lysine residues are attached to this linker using Fmoc-SPPS. The solubilising tag can be removed with 1M hydrazine or hydroxylamine solution.
references
A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis; M. T. Jacobsen, M. E. Petersen, X. Ye, M. Galibert, G. H. Lorimer, V. Aucagne and M. S. Kay; J Am Chem Soc 2016; 138: 11775-82. https://doi.org/10.1021/jacs.6b05719
Synthesis of hydrophobic insulin-based peptides using a helping hand strategy; M. M. Disotuar, M. E. Petersen, J. M. Nogueira, M. S. Kay and D. H. Chou; Org Biomol Chem 2019; 17: 1703-1708. https://doi.org/10.1039/c8ob01212a
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