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PFB-mercaptopropionyl-TOTA-Biotin
Chemical name: Perfluorobiphenyl-mercaptopropionyl-TOTA-Biotin // Synonyms: PFB-mercaptopropionyl-N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide, N-(15-oxo-17-((perfluoro-[1,1'-biphenyl]-4-yl)thio)-4,7,10-trioxa-14-azaheptadecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
- Product code:RL-4050
- Formula:C35H41F9N4O6S2
- Molecular weight:848.84 g/mol
- Purity :min.98%
from $427.50
description
Biotinylation reagent/linker for π-Clamp-mediated (Phe-Cys-Pro-Phe) site-selective Cysteine conjugation. This concept was developed by Bradley L. Pentelute lab.
references
Enzymatic "click" ligation: selective cysteine modification in polypeptides enabled by promiscuous glutathione S-transferase; C. Zhang, A. M. Spokoyny, Y. Zou, M. D. Simon, B. L. Pentelute; Angew Chem Int Ed Engl. 2013; 52(52): 14001-5. https://doi.org/10.1002/anie.201306430
Convergent diversity-oriented side-chain macrocyclization scan for unprotected polypeptides; Y. Zou, A. M. Spokoyny, C. Zhang, M. D. Simon, H. Yu, Y.-S. Lin, B. L. Pentelute; Org. Biomol. Chem. 2014; 12: 566-573. DOI https://doi.org/10.1039/C3OB42168F
π-Clamp-mediated cysteine conjugation; C. Zhang, M. Welborn, T. Zhu, N. J. Yang, M. S. Santos, T. Van Voorhis, B. L. Pentelute; Nat Chem. 2016; 8: 120-128. https://doi.org/10.1038/nchem.2413
Site-Specific Small Molecule Labeling of an Internal Loop in JC Polyomavirus Pentamers Using the π-Clamp-Mediated Cysteine Conjugation; J. A. Baccile, P. J. Voorhees, A. J. Chillo, M. Berry, R. Morgenstern, T. J. Schwertfeger, F. M. Rossi, C. D. S. Nelson; Chembiochem 22(21): 3037-3041. https://doi.org/10.1002/cbic.202100188
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