Chemical name: TMTH-sulfoximine beta-alanine amide TFA salt // Synonyms: TMTHSI-beta-Ala-NH2*TFA

  • Product code:RL-4190
  • Formula:C13H22N2O2S*CF3COOH
  • Molecular weight:270.39*114.02 g/mol

Starting at $187.50

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10 mg
25 mg
50 mg

The 7-membered CliCr® ring can be conveniently functionalized with a variety of linkers, e.g. via acylation, sulfonylation, N-alkylation, or carbamoylation. Hence, CliCr® reagents can be used in diverse applications for example for the construction of Antibody-Drug Conjugates (ADCs), for ex vivo cell modification (e.g. CAR-T), for small molecule-drug conjugates, for oligonucleotide conjugates as well as for diagnostic labelling of a variety of agents. Key benefits are its fast reactivity and increased yield, its hydrophilicity compared to other metal-free click reagents combined with its small size as well as its broad compatibility.

CliCr® is provided under an intellectual property license from Cristal Therapeutics. The trademark CliCr® is the property of the Supplier. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Cristal Therapeutics, Oxfordlaan 55, 6229 EV Maastricht


TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide-alkyne cycloaddition reactions; J. Weterings, C. J. F. Rijcken, H. Veldhuis, T. Meulemans, D. Hadavi, M. Timmers, M. Honing, H. Ippel, R. M. J. Liskamp; Chem. Sci. 2020; 11: 9011-9016.

Exploring the Chemical Properties and Medicinal Applications of Tetramethylthiocycloheptyne Sulfoximine Used in Strain-Promoted Azide–Alkyne Cycloaddition Reactions; M. Timmers, A. Kipper, R. Frey, S. Notermans, M. Voievudskyi, C. Wilson, N. Hentzen, M. Ringle, C. Bovino, B. Stump, C. J. F. Rijcken, T. Vermonden, I. Dijkgraaf, R. Liskamp; Pharmaceuticals 2023; 16: 1155.

Specific N-terminal attachment of TMTHSI linkers to native peptides and proteins for strain-promoted azide alkyne cycloaddition; M. Timmers, W. Peeters, N. J. Hauwert, C. J. F. Rijcken, T. Vermonden, I. Dijkgraaf, R. M. J. Liskamp; Chem. Commun. 2023;

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