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Boc-3-Amino-adamantane-1-carboxylic acid
Nom chimique: tert-Butyloxycarbonyl-3-Amino-adamantane-1-carboxylic acid
- n° Art.:BAA4620
- n° CAS:71740-76-6
- Formule:C16H25NO4
- Storage temperature:2-8°C
- Masse moléculaire:295,38 g/mol
from 300,00 €
description
The highly lipophilic, symmetrical adamantly motif is reported for its hydrophobic bulk and spherical shape, proposed by modelling to favor hydrophobic contacts in protein binding pockets. Thus, this non-natural adamantane g-amino acid building block can be used for structure-activity-relationship studies. Furthermore, adamantane is part of various medicinally important compounds.
references
Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D; A. Vulpetti, N. Ostermann, S. Randl. T. Yoon, A. M. Sweeney, F. Cumin, E. Lorthiois, S. Rüdisser, P. Erbel, J. Maibaum; ACS Med. Chem. Lett. 2018; 9(5): 490-495. https://doi.org/10.1021/acsmedchemlett.8b00104.
Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7-NMDA Receptor Antagonists; O. Karoutzou, S.-H. Kwak, S.-D. Lee, D. Martínez-Falguera, F. X. Sureda, S. Vázquez, Y.-C. Kim, M. Barniol-Xicota; Molecules 2018; 23(1): 230. https://doi.org/10.3390/molecules23010230.
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