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Fmoc-Ddax-L-Ala-OH
Nom chimique: N-alpha-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-6-((9-fluorenylmethyloxycarbonyl)amino)hexyl)-L-alanine // Synonymes: Fmoc-Ddax-Ala, Fmoc-Ddax-Ala-OH, (2S)-2-{[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexyl]amino}propanoic acid
- n° Art.:FAA8435
- n° CAS:2576507-90-7
- Formule:C32H38N2O6
- Storage temperature:2-8°C
- Masse moléculaire:546,65 g/mol
- Pureté:min. 99%
- Pureté Énantiomérique:min. 99,7%
from 234,00 €
description
Used as an Alanine-containing next-generation traceless "helping hand" solubilizing tag in SPPS. This solves the low reactivity issue of the tag with a peptide. Several Lysine residues are attached to this linker using Fmoc-SPPS. The solubilising tag can be removed with 1M hydrazine or hydroxylamine solution.
references
Chemical synthesis of Shiga toxin subunit B using a next-generation traceless “helping hand” solubilizing tag; J. M. Fulcher, M. E. Petersen, R. J. Giesler, Z. S. Cruz, D. M. Eckert, J. N. Francis, E. M. Kawamoto, M. T. Jacobsen, and M. S. Kay; Org Biomol Chem. 2019; 17; 10237-10244. https://doi.org/10.1039/C9OB02012H
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