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Fmoc-AEEP-DIM
Nom chimique: 3-(2-(2-(9-Fluorenylmethyl)oxycarbonylaminoethoxy)ethoxy)-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-propan-1-ol // Synonymes: Fmoc-Ddae-OH, (9H-fluoren-9-yl)methyl N-(2-{2-[3-(4,4-dimethyl- 2,6-dioxocyclohexylidene)-3-hydroxypropoxy]ethoxy}ethyl)carbamate
- n° Art.:RL-3270
- n° CAS:1988771-96-5
- Formule:C30H35NO7
- Storage temperature:-20°C
- Masse moléculaire:521,60 g/mol
- Pureté:min. 98%
from 100,00 €
description
Fmoc-Ddae-OH is used as a solubility-enhancing linker in the “helping hand” strategy for purification of highly insoluble peptides. Several Lysine residues are attached to this linker using Fmoc-SPPS. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution. For further modification and commercial use please refer to the claims in patent WO 2011058188 (A1).
references
A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis; M. T. Jacobsen, M. E. Petersen, X. Ye, M. Galibert, G. H. Lorimer, V. Aucagne and M. S. Kay; J Am Chem Soc 2016; 138: 11775-82. https://doi.org/10.1021/jacs.6b05719
Synthesis of hydrophobic insulin-based peptides using a helping hand strategy; M. M. Disotuar, M. E. Petersen, J. M. Nogueira, M. S. Kay and D. H. Chou; Org Biomol Chem 2019; 17: 1703-1708. https://doi.org/10.1039/c8ob01212a
Compounds and methods for purifying peptides produced by solid phase peptide synthesis; V. Aucagne, A. Delmas; 2011; WO2011058188A1; CNRS; U.S. Patent No. 9,073,969, 2015.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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