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Fmoc-AEEP-DMB
Nom chimique: (9-Fluorenylmethyloxycarbonyl)amino-PEG(2)-Dtpp // Synonymes: (9H-fluoren-9-yl)methyl N-(2-{2-[3-(1,3-dimethyl-2,4,6-trioxo-1,3-diazinan-5-ylidene)-3-hydroxypropoxy]ethoxy}ethyl)carbamate, (9H-fluoren-9-yl)methyl(2-(2-(3-(1,3-dimethyl-2,4,6-trioxotetrahydropyr imidin-5(2H)-ylidene)-3-hydroxypropoxy)ethoxy)ethy
- n° Art.:RL-3470
- Formule:C28H31N3O8
- Storage temperature:2-8°C
- Masse moléculaire:537,57 g/mol
- Pureté:min. 99%
from 120,00 €
description
Fmoc-AEEP-DMB is used as a solubility-enhancing linker in the “helping hand” strategy for purification of highly insoluble peptides. Several Lysine residues are attached to this linker using Fmoc-SPPS. The solubilising tag can be removed with 1M hydrazine or hydroxylamine solution.
references
A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis; M. T. Jacobsen, M. E. Petersen, X. Ye, M. Galibert, G. H. Lorimer, V. Aucagne and M. S. Kay; J Am Chem Soc 2016; 138: 11775-82. https://doi.org/10.1021/jacs.6b05719
Synthesis of hydrophobic insulin-based peptides using a helping hand strategy; M. M. Disotuar, M. E. Petersen, J. M. Nogueira, M. S. Kay and D. H. Chou; Org Biomol Chem 2019; 17: 1703-1708. https://doi.org/10.1039/c8ob01212a
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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