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Propargyl-PEG(5)-COOH
Nom chimique: 4,7,10,13,16-pentaoxanonadec-18-ynoic acid // Synonymes: Alkyne-PEG(5)-COOH, Alkyne-PEG(5)-acid, Propargyl-PEG(5)-acid
- n° Art.:PEG8170
- n° CAS:1245823-51-1
- Formule:C14H24O7
- Storage temperature:-20°C
- Masse moléculaire:304,34 g/mol
from 150,00 €
description
Heterobifunctional, PEGylated crosslinker bearing a carboxylic acid moiety and a propargyl group, which can be reacted with azide-containing compounds using Click chemistry. The hydrophilic PEG crosslinker facilitates solubility in biological applications.
references
Semisynthetic Analogs of the Antibiotic Fidaxomicin – Design, Synthesis, and Biological Evaluation; A. Dorst, R. Berg, C. G. W. Gertzen, D. Schäfle, K. Zerbe, M. Gwerder, S. D. Schnell, P. Sander, H. Gohlke, K. Gademann; ACS Med. Chem. Lett. 2020; 11(12): 2414-2420. https://doi.org/10.1021/acsmedchemlett.0c00381.
Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension; Q. Li, A. Barrett, B. Vijayakrishnan, A. Tiberghien, R. Beard, K. W. Rickert, K. L. Allen, R. J. Christie, M. Marelli, J. Harper, P. Howard, H. Wu, W. F. Dall‘Acqua, P. Tsui, C. Gao, M. J. Borrok; Bioconjugate Chem. 2019; 30(4): 1232-1243. https://doi.org/10.1021/acs.bioconjchem.9b00170.
Straightforward Glycoengineering Approach to Site-Specific Antibody-Pyrrolobenzodiazepine Conjugates; P. Thompson, E. Ezeadi, I. Hutchinson, R. Fleming, B. Bezabeh, J. Lin, S. Mao, C. Chen, L. Masterson, H. Zhong, D. Toader, P. Howard, H. Wu, C. Gao, N. Dimasi; ACS Med. Chem. Lett. 2016; 7(11): 1005-1008. https://doi.org/10.1021/acsmedchemlett.6b00278.
Site-Specific Antibody Labeling by Covalent Photoconjugation of Z Domains Functionalized for Alkyne-Azide Cycloaddition Reactions; A. Perols, M. A. Famme, A. E. Karlström; ChemBioChem 2015; 16(17): 2522-2529. https://doi.org/10.1002/cbic.201500300.
Enzyme-free translation of DNA into sequence-defined synthetic polymers structurally unrelated to nucleic acids; J. Niu, R. Hili, D. R. Liu; Nat. Chem. 2013; 5(4): 282-292. https://doi.org/10.1038/nchem.1577.
“Clickable”, polymerized liposomes as a versatile and stable platform for rapid optimization of their peripheral compositions; A. Kumar, U. J. Erasquin, G. Qin, K. Li, C. Cai; Chem. Commun. 2010; 46: 5746-5749. https://doi.org/10.1039/C0CC00784F.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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