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DBCO-PEG(3)-BisSulfonThiol-Linker
Nom chimique: Dibenzoazacyclooctyne-PEG(3)-BisSulfon-Thiol-Linker // Synonymes: 24-(azadibenzocyclooctyn-1-yl)-19,24-dioxo-4-(4-(3-tosyl-2-(tosylmethyl)propanoyl)benzoyl)-8,11,14-trioxa-4,18-diazatetracosane-1-sulfonic acid
- n° Art.:RL-2480
- Formule:C59H69N3O14S3
- Storage temperature:-20°C
- Masse moléculaire:1140,39 g/mol
from 290,00 €
description
Cyclooctyne linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with azides and tetrazines. The unique bis-sulfon linker integrates into existing disulfide bonds, eg. from enzymes or antibodies, maintaining the structural properties of the biomolecule.
references
Simon et al.; Facile Double-Functionalization of Designed Ankyrin Repeat Proteins using Click and Thiol Chemistries. Bioconjugate Chem. 2012; 23(2): 279.
Zeng et al.; 64Cu Core-Labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry. ACS Nano. 2012; 6(6): 5209.
Arumugam et al.; [18F]Azadibenzocyclooctyne ([18F]ADIBO): A biocompatible radioactive labeling synthon for peptides using catalyst free [3+2] cycloaddition. Bioorg. Med. Chem. Lett. 2011; 21: 6987.
Campbell-Verduyn et al.; Strain-Promoted Copper-Free Click Chemistry for 18F Radiolabeling of Bombesin. Angew. Chem. Int. Ed. 2011; 50: 11117.
Debets et al.; Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition. Chem. Commun. 2010: 46: 97.
Site-Directed Chemical Modification and Cross-Linking of a Monoclonal Antibody Using Equilibrium Transfer Alkylating Cross-Link Reagents; Frederick A. Liberatore, Robert D. Comeau, James M. McKearin, Daniel A. Pearson, Benjamin Q. Belonfa III, Stephen J. Brocchini, John Kath, Terri Phillips, Kira Oswell, and Richard G. Lawton A; Bioconjugate Chem. 1990; 7: 36-50.
Sulfhydryl Site-Specific Cross-Linking and Labeling of Monoclonal Antibodies by a Fluorescent Equilibrium Transfer Alkylation Cross-Link Reagent; Renato B. del Rosario, Richard L. Wahl, Stephen J. Brocchini, Richard G. Lawton, and Richard H. Smith; Bioconjugate Chem. 1990; 1: 51-59.
Streptavidin-biotinylated IgG Conjugates: a Simple Procedure for Reducing Polymer Formation; Renato B. Del Rosario, Lee Ann Baron; Richard G. Lawton and Richard L. Wahl; Nucl. Med. Biol. 1992; 19(3): 417-421.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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