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DBCO-COOH
Nom chimique: Dibenzoazacyclooctyne-carboxylic acid // Synonymes: DBCO-C6-acid, ADIBO-acid, Azadibenzocyclooctyne-carboxylic acid, 6-oxo-6-(azadibenzocyclooctyn-1-yl)hexanoic acid
- n° Art.:RL-2430
- n° CAS:1425485-72-8
- Formule:C21H19NO3
- Storage temperature:-20°C
- Masse moléculaire:333,38 g/mol
from 430,00 €
description
Cyclooctyne linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with azides and tetrazines. The carboxylic acid function can be used to form amid bonds with amines.
references
Simon et al.; Facile Double-Functionalization of Designed Ankyrin Repeat Proteins using Click and Thiol Chemistries. Bioconjugate Chem. 2012; 23(2): 279.
Zeng et al.; 64Cu Core-Labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry. ACS Nano. 2012; 6(6): 5209.
Arumugam et al.; [18F]Azadibenzocyclooctyne ([18F]ADIBO): A biocompatible radioactive labeling synthon for peptides using catalyst free [3+2] cycloaddition. Bioorg. Med. Chem.
Lett. 2011; 21: 6987.
Campbell-Verduyn et al.; Strain-Promoted Copper-Free Click Chemistry for 18F Radiolabeling of Bombesin. Angew. Chem. Int. Ed. 2011; 50: 11117.
Debets et al.; Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition. Chem. Commun. 2010: 46: 97.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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