DBCO-PEG(5)-COOH

Nom chimique: Dibenzoazacyclooctyne-penta(ethylene glycol)-propanoic acid // Synonymes: ADIBO-PEG(5)-acid

  • n° Art.:RL-2450
  • n° CAS:1870899-46-9
  • Formule:C32H40N2O9
  • Storage temperature:-20°C
  • Masse moléculaire:596,67 g/mol

from 380,00 €

Grouped product items
Nombre Unité de vente Prix SKU Disponibilité
25 mg
380,00 €
RL-2450.0025
<10 jour ouvrables
100 mg
690,00 €
RL-2450.0100
<10 jour ouvrables
500 mg
2 030,00 €
RL-2450.0500
<10 jour ouvrables
Fiches de données de sécurité
description

Cyclooctyne linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with azides and tetrazines. The carboxylic acid function can be used to form amid bonds with amines.

references

Simon et al.; Facile Double-Functionalization of Designed Ankyrin Repeat Proteins using Click and Thiol Chemistries. Bioconjugate Chem. 2012; 23(2): 279.

Zeng et al.; 64Cu Core-Labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry. ACS Nano. 2012; 6(6): 5209.

Arumugam et al.; [18F]Azadibenzocyclooctyne ([18F]ADIBO): A biocompatible radioactive labeling synthon for peptides using catalyst free [3+2] cycloaddition. Bioorg. Med. Chem. Lett. 2011; 21: 6987.

Campbell-Verduyn et al.; Strain-Promoted Copper-Free Click Chemistry for 18F Radiolabeling of Bombesin. Angew. Chem. Int. Ed. 2011; 50: 11117.

Debets et al.; Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition. Chem. Commun. 2010: 46: 97.

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