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Halo-PEG(4)-NH2*HCl
Nom chimique: 18-Chloro-3,6,9,12-tetraoxa-octadecan-1-amine hydrochloride // Synonymes: 18-Chloro-3,6,9,12-Tetraoxaoctadecan-1-amine hydrochloride, net-CAS 1141732-29-7
- n° Art.:RL-3690
- n° CAS:1261238-20-3
- Formule:C14H30ClNO4*HCl
- Storage temperature:-20°C
- Masse moléculaire:311,85*36,46 g/mol
from 400,00 €
description
This chloroalkane linker serves as ligand for a specific modified bacterial haloalkane dehalogenase. This is a reporter protein whose sequence can easily be fused to a gene of interest. The reaction between the chloroalkane linker and the enzyme is fast and irreversible under physiological conditions and the system has been used extensively to measure protein-protein interactions in cells.
references
HaloTag technology: a versatile platform for biomedical applications; C. G. England, H. Luo and W. Cai; Bioconjug Chem 2015; 26: 975-86. https://doi.org/10.1021/acs.bioconjchem.5b00191.
HaloTag: a novel protein labeling technology for cell imaging and protein analysis; G. V. Los, L. P. Encell, M. G. McDougall, D. D. Hartzell, N. Karassina, C. Zimprich, M. G. Wood, R. Learish, R. F. Ohana, M. Urh, D. Simpson, J. Mendez, K. Zimmerman, P. Otto, G. Vidugiris, J. Zhu, A. Darzins, D. H. Klaubert, R. F. Bulleit and K. V. Wood; ACS Chem Biol 2008; 3: 373-382. https://doi.org/10.1021/cb800025k.
A MedChem toolbox for cereblon-directed PROTACs; C. Steinebach, I. Sosiè, S. Lindner, A. Bricelj, F. Kohl, Y. L. D. Ng, M. Monschke, K. G. Wagner, J. Krönke, M. Gütschow; Med. Chem. Commun. 2019; 10: 1037-1041. https://doi.org/10.1039/C9MD00185A.
Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules; S. Tomoshige, M. Naito, Y. Hashimoto, M. Ishikawa; Org. Biomol. Chem. 2015; 13: 9746-9750. https://doi.org/10.1039/C5OB01395J.
Superresolution Imaging of Targeted Proteins in Fixed and Living Cells Using Photoactivatable Organic Fluorophores; H.-I. D. Lee, S. J. Lord, S. Iwanaga, K. Zhan, H. Xie, J. C. Williams, H. Wang, G. R. Bowman, E. D. Goley, L. Shapiro, R. J. Twieg, J. Rao, W. E. Moerner; J. Am. Chem. Soc. 2010; 132(43): 15099-15101. https://doi.org/10.1021/ja1044192.
In Vivo Stable Tumor-Specific Painting in Various Colors Using Dehalogenase-Based Protein-Tag Fluorescent Ligands; N. Kosaka, M. Ogawa, P. L. Choyke, N. Karassina, C. Corona, M. McDougall, D. T. Lynch, C. C. Hoyt, R. M. Levenson, G. V. Los, H. Kobayashi; Bioconjug. Chem. 2009; 20(7): 1367-1374. https://doi.org/10.1021/bc9001344.
Direct pH measurements by using subcellular targeting of 5 (and 6-)carboxyseminaphthorhodafluor in mammalian cells; H. Benink, M. McDougall, D. Klaubert, G. Los; Biotechniques 2009; 47(3): 769-74. https://doi.org/10.2144/000113220.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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